The fifth installment of the popular film franchise which is currently shooting in Canada will bring back a slew of actors from the previous films.Director Paul W.S. Anderson will return to helm Resident Evil: Retribution, while Milla Jovovich and Sienna Guillory will be reprising their roles as Alice and Jill Valentine. Punisher War Zone actor Colin Salmon has also been confirmed to appear alongside Michelle Rodriguez, Boris Kodjoe, Oded Fehr and Shawn Roberts; all veterans of the film franchise. Johann Urb — who will portray Leon Kennedy, Boris Kodjoe, Chinese actress Li Bingbing — as Ada Wong — and Kevin Durand will also star.

Characters from the previous films Chris Redfield (Wentworth Miller), Claire Redfield (Ali Larter) and K-mart (Spencer Locke) have been captured by the Umbrella Corporation. Retribution will also introduce the Las Plagas parasite, a breed of parasitic organisms in the Resident Evil games. Unlike the t-virus, which turned its victims into mindless zombies, the victims of Las Plagas become much stronger and highly resistant to pain, while working collectively to pursue their targets.